Tissue microstructure & metabolism
Diffusion MRI and multinuclear in vivo spectroscopy to quantify how tissue is organized and how it uses energy.
Medical Imaging Engineering & Physics
I develop MRI and in vivo NMR spectroscopy methods to measure tissue microstructure and metabolism — and apply them to understand injury, disease and recovery in the brain, muscle and body.
About
Dr. Michael Noseworthy is a Professor in the Department of Electrical and Computer Engineering at McMaster University and Director of Imaging Physics and Engineering at the Imaging Research Centre (IRC) of St. Joseph’s Healthcare Hamilton and at the Centre for Integrated and Advanced Medical Imaging (CIAMI). He is also Associate Chair (Research) in the Department of Medical Imaging and holds Special Professional Staff appointments in Radiology and Nuclear Medicine.
His research assesses normal and diseased tissue microstructure and how changes in that structure affect tissue metabolism. His group builds new MRI hardware, imaging pulse sequences and signal- and image-processing software, and applies them to physiological questions and disease. More recently the work has expanded to multimodal approaches that combine MRI with EEG, EMG and ultrasound, along with complex-systems mathematics and machine learning for image analysis.
He trained at the University of Guelph (BSc, MSc, PhD), held a postdoctoral fellowship in imaging physics at Sunnybrook (University of Toronto, Medical Biophysics), and was a Scientist and MRI Physicist at The Hospital for Sick Children and an Assistant Professor at the University of Toronto before joining St. Joseph’s and McMaster in 2003. From 2010 to 2020 he served as Co-Director of the McMaster School of Biomedical Engineering.
Research
From RF coils and pulse sequences to clinical studies — engineering the measurement, then using it to answer physiological questions.
Diffusion MRI and multinuclear in vivo spectroscopy to quantify how tissue is organized and how it uses energy.
Resting-state fMRI, DTI and spectroscopy to understand concussion and recovery — including the effects of exercise in youth.
Imaging skeletal muscle function, brown adipose tissue and organ fat to study exercise, obesity, diabetes and musculoskeletal disease.
RF coils, pulse sequences, compressed sensing and quality-control phantoms — including hyperpolarized ¹²⁹Xe lung MRI and 7 T methods.
Fusing MRI with EEG, EMG and ultrasound, and using fractal/complex-systems analysis and machine learning to extract new biomarkers.
People
The trainees and staff behind our research, and the projects they are working on.
Facilities
The Imaging Research Centre at St. Joseph’s Healthcare Hamilton and our engineering work at McMaster.
Publications
Peer-reviewed journal articles. Newly published papers are added automatically from my ORCID record. For citation metrics, see my Google Scholar profile.
News
Announcements, papers, talks and lab news.
On the road
Talks, posters and moments from meetings our group has attended. Select a conference to see its photos.
Teaching
Career
Contact
nosewor@mcmaster.ca
905-525-9140 ext. 23727
Imaging Research Centre
Fontbonne Building, Room 130A
St. Joseph’s Healthcare Hamilton
Dept. of Electrical & Computer Engineering
McMaster University, 1280 Main Street West
Hamilton, ON L8S 4L7, Canada